|
KMID : 0869620150320030234
|
|
Journal of Korean Society of Hospital Pharmacists
2015 Volume.32 No. 3 p.234 ~ p.246
|
|
|
Comparing the Efficacy and Safety of Caffeine and Theophylline Use in Korean Neonates with Neonatal Apnea
|
|
Kang Na-Young
Bae Hye-Jung
Shin Seung-Han
Cho Yoon-Sook
Kim Kwi-Suk
Han Hyeon-Ju
Kim Hyang-Sook
Kim Ee-Kyung
Kim Han-Suk
Choi Jung-Hwan
|
|
|
Abstract
|
|
|
|
Caffeine and theophylline are commonly used to treat neonatal apnea in Korea. To compare caffeine and theophylline therapy for neonatal apnea, a retrospective study was conducted. Subjects were classified by time: period Ⅰ received theophylline and period Ⅱ received caffeine for apnea. The short-term outcome for efficacy measured apnea frequency for a week while the longterm outcome measured the incidence of bronchopulmonary dysplasia(BPD). The safety outcome the measured cardiovascular, gastrointestinal, and neurological side effects. One hundred and thirty five preterm infants were included(71 in period Ⅰ, 64 in period Ⅱ). The mean gestational age was 29.3 weeks and the mean birth weight was 1.2 kg. During the 7-day therapy phase, period Ⅱ showed a lower mean frequency for apnea than period Ⅰ(2.0 events/day versus 1.6 events/day, p=0.3212) in addition to a Period Ⅱ showed lower rate of BPD(52.1% versus 46.9%, p=0.5433). significantly lower rate(94.4% versus 81.3%) of tachycardia(≥180 beats/min) occurred in period Ⅱ(OR=0.235, P=0.0202). It also took less time to reach full-feeding in period Ⅱ, although not significant. No drug-induced seizures occurred, but there was one case of drug-induced severe jitteriness in period I. In conclusion, caffeine can be considered as effective as theophylline in neonatal apnea and is safer than theophylline. Therefore caffeine is a better choice for neonatal apnea.
|
|
|
KEYWORD
|
|
|
Apnea, Infant, Newborn [MeSH], Infant, Premature [MeSH], Theophylline, Caffeine, Methylxanthine
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|